AUSPEX: System ArchitectureUnmanned Aerial Vehicles (UAVs) have become paramount for Search and Rescue (SAR) missions due to their ability to access hazardous and challenging environments and to rapidly provide cost-effective aerial situational awareness. Nevertheless, current UAV systems are designed for specific tasks, often focusing on benchmarking use cases. Therefore, they offer limited adaptability for the diverse decision-making demands of SAR missions. Furthermore, commercially available integrated UAV systems are non-open-source, preventing further extension with state-of-the-art decision-making algorithms. This paper introduces AUSPEX, a holistic, modular, and open-source framework tailored specifically for enhancing the decision-making capabilities of UAV systems. AUSPEX integrates diverse capabilities for knowledge representation, perception, planning and execution with state-of-the-art decision-making algorithms. Additionally, AUSPEX considers the heterogeneity of available UAV platforms and offers the possibility of including off-the-shelf as well as generic UAVs with an open architecture into the AUSPEX ecosystem. The framework relies only on open-source components to ensure transparency, as well as system scalability and extensibility. We demonstrate AUSPEX’s integration with the Unreal Engine based simulation framework REAP for software-in-the-loop validation and a platform-independent graphical user interface (AUGUR). We demonstrate how AUSPEX can be used for generic scenarios in SAR missions while highlighting its potential for future extensibility.